منابع مشابه
Clinical Reversal of Multidrug Resistance.
Reversal of drug resistance offers the hope of increasing the efficacy of conventional chemotherapy. We tested dexverapamil as a P-glycoprotein antagonist in combination with EPOCH chemotherapy in refractory non-Hodgkin's lymphoma. In a cross-over design, dexverapamil was added to EPOCH after disease stabilization or progression occurred. Objective responses were observed in 10 of 41 assessable...
متن کاملReversal of Multidrug Resistance by Lipophilic Drugs1
The phenomenon of multidrug resistance implies that a wide spectrum of structurally and functionally unrelated chemotherapeutic drugs are recognized and processed by the molecular system which protects multidrug-resistant (MDR) cells against lipophilic cytotoxic drugs. This suggests that lipophilic agents with low toxicity may also be recognized and processed by this molecular system. At high c...
متن کاملReversal of multidrug resistance by RU 486.
P-Glycoproteins represent a family of drug efflux proteins that convey multidrug resistance to cells in which they are expressed. This phenomenon can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug efflux. We report that the antiprogestin RU 486 can reverse multidrug resistance in cells overexpressing the m...
متن کاملReversal of Multidrug Resistance by RU 4861
P-Glycoprotelns represent a family of drug efflux proteins that convey multidrug resistance to cells In which they are expressed. This phenome non can lower the efficacy of drugs used in chemotherapy. The steroid progesterone has been shown to bind P-glycoproteins and inhibit their drug emux. We report that the antiprogestin RU 486 can reverse multi drug resistance In cells overexpressing the m...
متن کاملFluoxetine and reversal of multidrug resistance.
This review centers on recent findings with respect to modulating cancer multidrug resistance (MDR) with the well-known antidepressant fluoxetine (prozac). The MDR phenomena and mechanisms are discussed, including the roles of ABC transporters as MDR-pumps and the potential involvement of cancer stem cells. The three generations of MDR reversal agents (chemosensitizers) are reviewed, introducin...
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ژورنال
عنوان ژورنال: The Oncologist
سال: 1996
ISSN: 1083-7159,1549-490X
DOI: 10.1634/theoncologist.1-4-269